Magnesium: Physiology and Pharmacology

Magnesium is a cofactor in more 300 enzymatic biochemical reactions in the body. It is involved in energy metabolism, hormone binding, muscle contraction, cardiac excitation and neurotransmitter release. It is primarily absorbed in the small intestine and excreted out of the body by the kidney. It has been extensively studied. It has been shown to have a marked effect on potassium and sodium levels and is involved in direct production of energy. Low levels are strongly linked to dementia, restless leg syndrome, chronic fatigue syndrome. Magnesium is used to reduce asthma exacerbation, halt preclamsia and eclampsia in obstetric medicine, reduce cardiac heart arrhythmia, increase blood flow and has a direct effect on excitatory hormone release. This means that when the adrenal glands release catecholamines, like norepinephrine and epinephrine, Magnesium can actually calm that response.

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